Evidence for CAD (coronary artery disease) therapies

The framingham heart study has identified hypertension as a risk factor for cornary artery disease and ace inhibitors and angiotensin receptor blockers may provide further benefit above BP reduction (HOPE, ONTARGET), though this is controversial (VALUE).

Statins reduce mortality (4S).

Whilst coronary artery bypass grafting appears to reduce mortality in patients in high-risk diabetics (BARI-2D, FREEDOM) and patients with multi-vessel or left main stem disease (ASCERT, SYNTAX), percutaneous coronary intervention is much more controversial; COURAGE showed no benefit for PCI over medical therapy, though FAME-2 may have shown some benefit.