Problem Acute ischaemic stroke
Format -
Treatment rt-PA
Control Placebo
Population 620 patients
Inclusion criteria -
Exclusion criteria -
Follow-up 90 days
Primary endpoint Barthel Index (BI) and modified Rankin Scale (RS) at 90 days
Secondary endpoint(s) combined BI and RS, Scandinavian Stroke Scale (SSS) at 90 days, and 30-day mortality
Details Treatment within 6 hours
Brief summary:
PAPER: Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)
Date 4 Oct 1995
Journal JAMA. 1995 Oct 4;274(13):1017-25.
Information rt-PA given within 6 hours

Improvement in some functional measures and neuro. outcome
-In subgroup of patients with moderate-severe neuro
-& without extended infarct on CT

Therefore necessary to be able to identify this subgroup - difficult