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DASH TRIAL |
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|---|---|
| Problem | HTN (SBP <160; DBP 80-95 mmHg) |
| Format | Multicenter, non-blind, parallel-group, randomized, controlled trial |
| Treatment | Diet modification |
| Control | - |
| Population | 459 patients |
| Inclusion criteria | Aged 22 or over Mean SBP <160mmHg Mean DBP 80-95mmHg |
| Exclusion criteria | Use of medications that affect BP Poorly controlled DM Cardiovascular event within 6 months CKD Chronic diseases that may interfere with study participation Pregnany or lactation BMI >35 kg/m2 Unwilling to stop vitamins, mineral supplements, or antacids containing Mg or Ca >14 alcoholic drinks per week |
| Follow-up | 8 week intervention phase (following run-in) |
| Primary endpoint | Changes in resting DBP |
| Secondary endpoint(s) | Changes in resting SBP Changes in ambulatory DBP Changes in ambulatory SBP |
| Details | - |
| Brief summary: | Small but significant BP reductions from diet control |
| PAPER: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. | |
|---|---|
| Date | 17 Apr 1997 |
| Journal | N Engl J Med. 1997 Apr 17;336(16):1117-24. |
| Information | Patients assigned to 8 weeks of either -'Typical American' control diet -Diet rich in fruits and vegetables -\combination\" diet rich in fruits, vegetables, low-fat dairy products, with reduced saturated and total fat Reduced sodium intake and alcohol consumption recommended for all patients Fruit and veg. diet reduced BP by 2.8/1.1 mmHg vs. control Combined diet reduced by by BP by 5.5/3.0 mmHg vs. control -Results seen within 2 weeks -Continued until end of intervention (6 weeks) |