Problem STEMI
Format Single-center, prospective, randomized, open trial involving the blinded evaluation of end points
Treatment Thrombus aspiration
Control Conventional PCI
Population 1071 patients
Inclusion criteria Symptoms suggesting acute myocardial ischemia lasting more than 30 minutes
The onset of symptoms less than 12 hours previously
ST-segment elevation of more than 0.1 mV in two or more leads on the ECG
Exclusion criteria Performance of a rescue PCI after thrombolysis
Known existence of a disease resulting in a life expectancy of less than 6 months
Lack of informed consent.
Follow-up 30 days
Primary endpoint Postprocedural frequency of a myocardial blush grade of 0 or 1
Secondary endpoint(s) Postprocedural frequencies of a Thrombolysis in Myocardial Infarction (TIMI) flow grade of 3
Complete resolution of ST-segment elevation
The absence of persistent ST-segment deviation
Rarget-vessel revascularization
Combination of major adverse cardiac events
Details -
Brief summary: Thrombus aspiration during PCI for STEMI improves mortality
PAPER: Thrombus aspiration during primary percutaneous coronary intervention.
Date 7 Feb 2008
Journal N Engl J Med. 2008 Feb 7;358(6):557-67.
Information Thrombus aspiration in STEMI assoc. with:
-Improved blush grade on post-PCI angio (P<0.001)
-Improved resolution of ST-segment elevation (P<0.001)
-Improved mortality @ 30d (P=0.003)
-Lower adverse events (P<0.001)
All irrespective of baseline clinical/angio characteristics

N.B. Single centre
PAPER: Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study
Date 7 Jun 2008
Journal Lancet. 2008 Jun 7;371(9628):1915-20.
Information Thrombus aspiration for STEMI @ 1 year
-Improved cardiac mortality (3.6% vs. 6.7%; p=0.020)
-Improved cardiac mortality and non-fatal reinfarction (5.6% vs. 9.9%; p=0.009)